Up to three simultaneous players control the monsters George
(a King Kong-like gorilla), Lizzie (a Godzilla-like dinosaur/lizard),
or Ralph (a giant werewolf), created from humans who were mutated by
various methods. They need to destroy all buildings in a high-rise
city to advance to the next city. On their way they can destroy
helicopters, tanks, taxis, police cars, boats, and trolleys, as well
as eat people.
The monsters can jump and climb buildings, and attack enemies and buildings with punches. Buildings also take damage when jumped on.
The player receives damage from enemy bullets, grenades, shells, etc., or from falls. Damage can be recovered by eating the right food, such as fruit, roast chicken, or soldiers. If a monster takes too much damage, it reverts back into a naked human and starts walking off the screen sideways covering their private parts with their hands. (while in this state, the player can then be eaten by another player.) If the player continues, the human will mutate back into the monster (or fly on a blimp if off screen when player presses Start.) with a full life bar.
Smashing open windows generally reveals an item or person of interest, which may be either helpful or harmful. Helpful items include food or money, dangerous ones include bombs, electrical appliances, and cigarettes. Some items can be both, for example a toaster is dangerous until the toast pops up, and a photographer must be eaten quickly before he dazzles the player's monster with his flash, causing it to fall. If a monster eats a toilet, they immediately go into a choking fit that is quite humorous to watch.
When a civilian is present waving their hands out a window, (signalling for help), if one of the creatures grabs them, that player's points meter begins to rapidly increment. This was the 'undocumented' trick to achieving a record score in the game. The only problem is that each player can hold only one type of person. George can hold women, Lizzie can hold men, and Ralph can hold businessmen.
Rampage takes place through 128 days through cities across North America. The game starts in Peoria, Illinois and ends in Plano, Illinois. (Wikipedia)